A wave of spatial transcriptomics studies has produced gene-expression atlases that span entire organs and whole organisms, from mouse embryos to the roundworm C. elegans to 31 human tissues. These ...

Tumors contain many different types of cells organized in complex spatial patterns that can influence how the disease progresses. Because of this, it is hard to predict how a tumor will develop and ...

Spatial biology captures molecular complexity by preserving the physical context of cells in their native environments. From deciphering RNA dynamics within stress granules to scaling molecular ...

Andreas Pfenning discusses the techniques being developed and used to study neuronal heterogeneity and the therapeutic potential of his work.

Rare cancers encompass a heterogeneous group of malignancies characterized by low incidence and prevalence but, often, disproportionately high mortality ...

Many biological functions and systems are influenced by how gene expression is spatially distributed, from subcellular through to tissue, organ, or at embryonic level. Our understanding of these ...

Applying single-cell RNA sequencing has led researchers to be able to profile the entire transcriptome of cells. However, these transcriptomes prove difficult to link back to their original location ...

This figure shows how the STAIG framework can successfully identify spatial domains by integrating image processing and contrastive learning to analyze spatial transcriptomics data effectively.

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

Spatial transcriptomics (ST) emerges as a pivotal technique for cataloging gene expression across tissue sections while retaining crucial locational data. Traditional methodologies, encompassing bulk ...

Mount Sinai researchers have published the first organ-wide human skin spatial atlas from across the body. It provides an ...